Defense penetration 2007

Description:Thus, workers may have compromised skin due to chemical or mechanical damage, due to different medical conditions eczema, dermatitis, skin irritation or related to occupational scenarios involving prolonged wet work. The present study used the OECD guideline procedures to study the in vitro percutaneous penetration through human skin of a number of model substances glyphosat, caffeine, benzoic acid, malathion covering a range of solubilities. Further, we studied the extent to which a slightly damaged skin would change the rate, the amount absorbed during dermal exposure and the distribution of chemical deposition between epidermis and dermis. The present study demonstrates that a limited damage to the skin significantly increases the permeability coefficient K p as well as total percutaneous penetration of chemicals, and most significantly for those compounds that due to their physicochemical characteristics the most hydrophilic as well as the most lipophilic have low penetration rates through intact skin. The present experiment not only confirms the proportionality between lipophilicity and potential for percutaneous penetration, but also illustrates that at a certain degree of lipophilicity of a model compound, the different skin compartments become more attractive for temporary deposition of model compounds. Moreover, a clear change from epidermal deposition towards a dominating dermis deposition of chemicals temporarily deposited within the skin is seen following damage to the skin barrier.

Views: 6404 Date: 2018-09-20 Favorited: 67